{"id":165285,"date":"2023-09-11T10:38:16","date_gmt":"2023-09-11T13:38:16","guid":{"rendered":"https:\/\/www.informelitoral.com.ar\/?p=165285"},"modified":"2023-09-11T16:45:30","modified_gmt":"2023-09-11T19:45:30","slug":"cultivaron-con-exito-un-organo-humanizado-dentro-de-un-cerdo","status":"publish","type":"post","link":"https:\/\/informelitoral.com.ar\/cultivaron-con-exito-un-organo-humanizado-dentro-de-un-cerdo\/","title":{"rendered":"Cultivaron con \u00e9xito un \u00f3rgano humanizado dentro de un cerdo"},"content":{"rendered":"<p>Cient\u00edficos de instituciones chinas cultivaron embriones con una combinaci\u00f3n de c\u00e9lulas humanas y porcinas que desarrollaron ri\u00f1ones humanizados normales. Los investigadores se enfocaron en la creaci\u00f3n de ri\u00f1ones porque son uno de los primeros \u00f3rganos en desarrollarse y su uso para trasplante en humanos es muy com\u00fan.<\/p>\n<p>Seg\u00fan public\u00f3 el sitio de la Asociaci\u00f3n estadounidense para el avance de la ciencia (AAAS), a nivel mundial solo se hab\u00eda cultivado en cerdos sangre o m\u00fasculo esquel\u00e9tico humano, por lo que ahora, se logr\u00f3 por primera vez cultivar un \u00f3rgano s\u00f3lido humanizado dentro de otra especie animal.<\/p>\n<p>De acuerdo a lo que explic\u00f3 explic\u00f3 uno de los autores principales Liangxue Lai, de la Academia de Ciencias de China: \u00abSe han producido \u00f3rganos de rata en ratones y \u00f3rganos de rat\u00f3n en ratas, pero los intentos anteriores de cultivar \u00f3rganos humanos en cerdos no han tenido \u00e9xito. Nuestro enfoque mejora la integraci\u00f3n de c\u00e9lulas humanas en los tejidos receptores y nos permite cultivar \u00f3rganos humanos en cerdos\u00bb, subray\u00f3.<\/p>\n<p><img decoding=\"async\" class=\"img-responsive ls-is-cached lazyloaded\" src=\"https:\/\/www.rosario3.com\/export\/sites\/rosario3\/img\/2023\/09\/08\/gr2.jpg_415156152.jpg\" alt=\"gr2.jpg_415156152\" width=\"auto\" height=\"auto\" data-src=\"https:\/\/www.rosario3.com\/export\/sites\/rosario3\/img\/2023\/09\/08\/gr2.jpg_415156152.jpg\" \/><\/p>\n<p>El equipo dise\u00f1\u00f3 un embri\u00f3n de cerdo unicelular gen\u00e9ticamente modificado incapaz de desarrollar ri\u00f1ones para evitar la competencia. Luego, cre\u00f3 c\u00e9lulas madre humanas pluripotentes menos propensas a la autodestrucci\u00f3n y las convirtieron en c\u00e9lulas embrionarias humanas tempranas, llamadas \u00abingenuas\u00bb, con capacidad de crear tejido embrionario. Por \u00faltimo, cultiv\u00f3 miles de estos embriones quim\u00e9ricos en condiciones optimizadas, para proporcionar condiciones de desarrollo a las c\u00e9lulas humanas y porcinas, antes de transferirlos a 13 madres sustitutas.<\/p>\n<p>Los investigadores recolectaron embriones quim\u00e9ricos para analizarlos a los 25 y a los 28 d\u00edas despu\u00e9s de la implantaci\u00f3n y descubrieron que ten\u00edan ri\u00f1ones estructuralmente normales, compuestos por un 50-60 % de c\u00e9lulas humanas. El trabajo se public\u00f3 en la revista especializada Cell Stem Cell.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El objetivo a largo plazo es optimizar esta tecnolog\u00eda para el trasplante de \u00f3rganos humanos. Los detalles.<\/p>\n","protected":false},"author":8,"featured_media":165290,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[8,1595],"tags":[533,487,4376],"class_list":{"0":"post-165285","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-internacionales","8":"category-salud","9":"tag-cerdos","10":"tag-china","11":"tag-organo-humanizado"},"yoast_head":"<title>Cultivaron con \u00e9xito un \u00f3rgano humanizado dentro de un cerdo - Informe Litoral<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/informelitoral.com.ar\/cultivaron-con-exito-un-organo-humanizado-dentro-de-un-cerdo\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cultivaron con \u00e9xito un \u00f3rgano humanizado dentro de un cerdo - Informe Litoral\" \/>\n<meta property=\"og:description\" content=\"El objetivo a largo plazo es optimizar esta tecnolog\u00eda para el trasplante de \u00f3rganos humanos. 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